Home GPCR & G Protein Adrenergic Receptor activator Isoferulic Acid For research use only.

Isoferulic Acid

Synonyms: Hesperetic acid, Hesperetate, Isoferulate

Isoferulic acid (Hesperetic acid, Hesperetate, Isoferulate), a major active ingredient of Cimicifuga heracleifolia, shows anti-inflammatory, antiviral, antioxidant, and antidiabetic properties. Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) is a cinnamic acid derivative that has antidiabetic activity. Isoferulic acid binds to and activates α1-adrenergic receptors (IC50=1.4 µM) to enhance secretion of β-endorphin (EC50=52.2 nM) and increase glucose use.

Isoferulic Acid Chemical Structure

Isoferulic Acid Chemical Structure

CAS No. 537-73-5

Purity & Quality Control

Batch: S376401 DMSO]38 mg/mL]false]]]false]]]false Purity: 99.98%
99.98

Isoferulic Acid Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Isoferulic acid (Hesperetic acid, Hesperetate, Isoferulate), a major active ingredient of Cimicifuga heracleifolia, shows anti-inflammatory, antiviral, antioxidant, and antidiabetic properties. Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) is a cinnamic acid derivative that has antidiabetic activity. Isoferulic acid binds to and activates α1-adrenergic receptors (IC50=1.4 µM) to enhance secretion of β-endorphin (EC50=52.2 nM) and increase glucose use.
In vitro
In vitro Isoferulic acid can activate the α1A-AR to enhance glucose uptake into C2C12 cells[1]. Isoferulic acid is a potent inhibitors against intestinal maltase with an IC50 of 0.76±0.03 mM and it is also an intestinal sucrase inhibitor with IC50 of 0.45±0.01 mM. It activates α1-adrenoceptors to enhance the secretion of β-endorphin, which stimulates the opioid μ-receptors to increase glucose use and/or reduce hepatic gluconeogenesis, resulting in a reduction of the plasma glucose concentration[3].
In Vivo
In vivo Isoferulic acid increases the glucose utilization in skeletal muscle and reduces the hepatic gluconeogenesis in insulin-deficient rat[1]. Isoferulic acid can inhibit hepatic gluconeogenesis and/or increase the glucose utilization in peripheral tissue to lower plasma glucose in diabetic rats lacking insulin[2].
Animal Research Animal Models Male Wistar rats (diabetic model)
Dosages 1.0, 5.0 and 10.0 mg/kg
Administration i.v.

Chemical Information & Solubility

Molecular Weight 194.18 Formula

C10H10O4
CAS No. 537-73-5 SDF Download Isoferulic Acid SDF
Smiles COC1=C(C=C(C=C1)C=CC(=O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 38 mg/mL ( (195.69 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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